Part 2: Understanding Undermethylation and Overmethylation

Paula Gallagher on 11/28/2023

Methylation, a fundamental biochemical process in the body, plays a crucial role in maintaining health and well-being. However, imbalances in methylation can lead to two distinct conditions: undermethylation or overmethylation. In the second part of this series about methylation, we will explore the characteristics of each, how they impact health, symptoms associated with undermethylation and overmethylation, and tests that can help determine a methylation disorder.

Undermethylation

What is Undermethylation?

Undermethylation occurs when there is an insufficient amount of methyl groups (CH3) available in the body. This deficiency can affect various processes, including neurotransmitter function, DNA regulation, and detoxification.

Symptoms of Undermethylation

Depression and low mood: Undermethylation has been associated with lower levels of neurotransmitters like serotonin, contributing to symptoms of depression and low mood.

Histamine intolerance: Individuals with undermethylation tendencies may experience issues with histamine regulation, leading to symptoms such as headaches, allergies, and skin problems.

Obsessive-compulsive traits: Undermethylation has been linked to obsessive-compulsive tendencies and perfectionism.

Fatigue: Insufficient methylation may impact energy production, leading to feelings of fatigue and low energy levels.

Impaired immune function: Undermethylation can affect immune system function, potentially increasing susceptibility to infections and illnesses.

Overmethylation

What is Overmethylation?

Overmethylation occurs when there is an excess of methyl groups (CH3) in the body, disrupting the delicate balance of biochemical processes.

Symptoms of Overmethylation

Anxiety and restlessness: Overmethylation may lead to elevated levels of neurotransmitters, contributing to symptoms like anxiety, restlessness, and racing thoughts.

Insomnia: Sleep disturbances, including difficulty falling asleep or staying asleep, can be associated with overmethylation.

Digestive issues: Overmethylation may impact digestive function, leading to symptoms such as bloating, gas, and irritable bowel-like symptoms.

Allergies and sensitivities: Individuals with overmethylation tendencies may be more prone to allergies and sensitivities.

Histamine intolerance: Overmethylation can contribute to elevated histamine levels, leading to symptoms like headaches, nasal congestion, and skin issues.

Testing for Methylation Disorders

Whole Blood Histamine: Whole blood histamine levels are a marker for methylation, a critical biochemical pathway necessary for the production of neurotransmitters such serotonin, dopamine, norepinephrine and epinephrine. Genetic abnormalities in methylation can result in either the overproduction or underproduction of these important brain neurotransmitters. People that overproduce neurotransmitters (over-methylators) often have high anxiety, panic disorders, and chemical sensitivities. Individuals who under-produce neurotransmitters (under-methylators) often exhibit depression, compulsive behaviors, and perfectionism. Our Brain Chemistry Panel includes whole blood histamine as one of the important biomarkers for assessing biochemical imbalances.

Supplements

Addressing methylation disorders often involves a comprehensive approach that includes targeted supplementation. Based on testing, we can help personalize a plan to address your concerns.

Understanding the distinctions between undermethylation and overmethylation is crucial for addressing methylation disorders effectively. Both conditions have unique symptoms and require tailored approaches to supplementation and lifestyle.

If you suspect a methylation disorder, consulting with a healthcare professional is recommended. Comprehensive testing, including histamine level testing, can provide valuable insights, guiding personalized interventions for better health. By navigating the complexities of methylation, individuals can embark on a journey toward balance and well-being with informed choices and targeted support.

Next this in methylation series: Who is Dr. William Walsh, and why he believes addressing imbalances in nutrients and neurotransmitters can improve mental well-being.

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