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The Estrobolome: How Gut Bacteria Influence Estrogen Balance
Paula Gallagher on
When most people think about estrogen, they immediately think about the ovaries. But there’s another powerful system that plays a major role in hormone balance—your gut. Inside your microbiome lives a unique community of bacteria called the estrobolome, and it has a surprisingly big impact on how your body metabolizes and eliminates estrogen.
For women navigating PMS, heavy periods, perimenopause, fibroids, endometriosis, or symptoms of estrogen dominance, supporting the estrobolome can make a dramatic difference in how they feel.
Below, we’ll explore what the estrobolome is, why it matters, and how nutrients such as fiber, probiotics, DIM, and calcium-D-glucarate can help maintain healthy estrogen balance.
What Exactly Is the Estrobolome?
The estrobolome refers to the subset of gut bacteria whose enzymes influence the circulation and detoxification of estrogen. While your liver prepares estrogen for removal, your gut plays the final—and arguably most important—role: eliminating it.
When the gut is healthy and diverse, the estrobolome helps metabolize estrogen properly and ensures excess estrogen exits the body. But when the gut microbiome becomes imbalanced due to stress, poor diet, antibiotics, low fiber intake, or inflammation, an enzyme called beta-glucuronidase can become overactive.
This enzyme can “unpackage” detoxified estrogen, sending it back into circulation.
This can contribute to:
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PMS or PMDD
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Heavy periods
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Breast tenderness
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Hormonal acne
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Mood swings
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Weight gain (especially hips/thighs)
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Perimenopausal symptoms
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Fibroids or endometriosis
This gut–hormone connection is one of the most important—and most overlooked—areas of women’s health.
4 Key Ways to Support a Healthy Estrobolome
Below are four clinically relevant nutrients that support estrogen balance by optimizing gut function and detoxification pathways.
1. Fiber: The Foundation of Estrogen Detoxification
Fiber is one of the most powerful—yet overlooked—tools for hormone balance. It binds to estrogen in the digestive tract and helps eliminate it through bowel movements.
Why Fiber Matters
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Helps carry excess estrogen out of the body
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Reduces constipation (a major contributor to estrogen reabsorption)
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Feeds beneficial bacteria that support the estrobolome
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Promotes healthy bowel movements to prevent hormone recirculation
Best Sources of Fiber
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Flaxseed
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Chia seeds
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Psyllium husk
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Oats
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Beans and lentils
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Vegetables and berries
Most women benefit from 25–35 grams of fiber per day.
2. Probiotics: Nourishing the Gut Bacteria That Balance Estrogen
Probiotics help restore and maintain a healthy microbiome—and a healthy microbiome keeps beta-glucuronidase activity in a normal range. This supports better estrogen detoxification and reduces symptoms associated with estrogen imbalance.
3. DIM: Improving Estrogen Metabolism at the Cellular Level
DIM (diindolylmethane) is a plant compound found in cruciferous vegetables such as broccoli, cauliflower, and Brussels sprouts. It supports healthy estrogen metabolism by shifting estrogen toward protective pathways.
Benefits of DIM
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Reduces estrogen dominance symptoms
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Supports hormonal acne
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Helps promote a balanced ratio of estrogen metabolites
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Useful during PMS and perimenopause
Because DIM is potent, women taking hormone therapy or prescription medications should discuss it with a practitioner before use.
4. Calcium-D-Glucarate: Supporting Healthy Estrogen Excretion
Calcium-D-glucarate (CDG) supports both liver detoxification and gut elimination. It naturally reduces beta-glucuronidase activity, preventing detoxified estrogen from being reabsorbed.
Why CDG Is Beneficial
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Enhances phase II liver detoxification
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Supports the safe removal of excess estrogen
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Helps with symptoms associated with estrogen excess
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Works synergistically with fiber and probiotics
CDG is a popular choice for women looking for natural support for estrogen balance.
The Bottom Line: Your Gut Is a Hormone-Balancing Organ
Hormone balance isn’t just about the ovaries—it’s about the entire body, especially the gut.
By supporting the estrobolome with:
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Fiber (to bind estrogen)
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Probiotics (to restore a healthy microbiome)
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DIM (to support estrogen metabolism)
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Calcium-D-Glucarate (to prevent estrogen recirculation)
Women can experience more predictable cycles, improved mood, better energy, fewer PMS symptoms, and smoother perimenopausal transitions.
This gut–hormone connection is one of the clearest examples of how integrative care—nutrition, supplements, lifestyle support, and personalized pharmacy services—can help women thrive.
FAQ About The Estrobolome:
What is the estrobolome?
The estrobolome is the collection of gut bacteria that helps regulate how estrogen is metabolized and eliminated from the body. It plays a major role in hormone balance.
How do I know if my estrobolome is imbalanced?
Common signs include PMS, heavy periods, hormonal acne, breast tenderness, bloating, fibroids, endometriosis, and symptoms of estrogen dominance.
What supplements support estrogen detoxification?
Fiber, probiotics, DIM, and calcium-D-glucarate are the most researched nutrients for improving estrogen metabolism and reducing recirculation.
Is DIM safe for everyone?
DIM is effective but potent. Women on hormone therapy or prescription medications should consult a practitioner before use.
How long does it take to see improvement?
Most women notice benefits within 6–12 weeks, especially when combining supplements with gut-supportive nutrition and lifestyle habits.
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PATHWAY
Women’s 85 Billion Probiotic
No reviews
$46.14
$70.99
This whole food probiotic formula is designed to specifically meet the unique needs of women and support vaginal health and overall digestive function. It contains organic food-sourced vitamins and minerals, a blend of organic fruits, veggies, and mushrooms, probiotic strains derived from kefir cultures, and an ultra-digestive enzyme blend.
Suggested Use: Adults take two (2) vegetarian capsules with meals or as directed by a health care professional.
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PATHWAY
ULTRA DIM 200 MG
No reviews
$17.54
$26.99
Imbalances in hormones, particularly estrogen and progesterone, can significantly influence a woman’s monthly cycle. Excess estrogens are linked to irregular, heavy, or uncomfortable menstrual cycles. These hormone imbalances can also contribute to breast tenderness, bloating, and mood changes related to PMS. High estrogen levels in women can increase the risk of a number of health concerns, including cancer, endometriosis, fibroids, polycystic ovarian syndrome (PCOS) and Insulin Resistance. In men, while estrogen is essential for proper bodily functions, excessive levels can cause health problems, including infertility, erectile dysfunction, and depression. Research shows that 20.2% of male patients have elevated estrogen levels, with older men, those using testosterone therapy, and individuals with obesity being more susceptible.
Features:
Supports healthy hormonal balance and estrogen metabolism
200 mg DIM [Diindolylmethane], is a phytonutrient found naturally in cruciferous vegetables
100 mg Organic Broccoli Powder [Brassica Oleracea Italica]
Citrus Bioflavonoid Complex delivering 3.00% Hesperidin
Contains no sugar, salt, dairy, yeast, wheat, gluten, eggs, peanuts, soy, tree nuts, fish, shellfish, sesame, preservatives, artificial colors or flavors
Gluten Free, Non GMO & Vegan
Benefits:
Clinically studied ingredients support healthy hormonal balance and estrogen metabolism in both women and men.
Ultra DIM combines DIM, broccoli seed extract, and a citrus bioflavonoid complex [with 3% Hespederin] to help the body metabolize and detoxify excess estrogen.
DIM works by helping to promote 2-hydroxyestrone production, supporting a healthy 2:16 hydroxyestrone ratio.
DIM is considered a estrogen blocker because it blocks an enzyme called aromatase that converts testosterone into estrogen, which can support your testosterone levels.
Organic broccoli powder is a great source of calcium, vitamin K, vitamin C, chromium and folate and is sodium and fat-free. Like other cruciferous vegetables, it may help lower the risk of heart disease. Broccoli contains a compound called sulforaphane which may help with the healthy aging process.
Hesperidin, a flavonoid commonly found in citrus fruits, is known for its antioxidant properties, which help protect cells from damage caused by free radicals. Studies suggest hesperidin may also support heart health by strengthening blood vessels and reducing inflammation.
Suggested Use:
As a dietary supplement, adults take one (1) vegan capsule daily with a meal, or as directed by a health care professional.
Storage Instructions:
Store in a cool, dry place
Keep away from direct light
KEEP OUT OF REACH OF PETS & CHILDREN.
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INTEGRATIVE THERAPEUTICS
Calcium D-Glucarate
No reviews
$43.99
$43.99
Calcium D-Glucarate is a form of D-glucaric acid complexed with calcium. It has been shown to support immune system function, promote estrogen metabolism and support the body's detoxification systems.
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