GLP-1 Constipation Relief: Why Ozempic & Mounjaro Cause Digestive Issues—and What Helps

Paula Gallagher on 08/27/2025

GLP-1 medications like Ozempic® (semaglutide), Wegovy®, Mounjaro® (tirzepatide), and Zepbound™ are transforming care for people with type 2 diabetes and those pursuing weight loss. These powerful drugs regulate blood sugar, control appetite, and promote weight reduction by mimicking the GLP-1 hormone.

But if you’ve searched for terms like:

“Semaglutide constipation”
“Mounjaro bloating”
“GLP-1 constipation relief”

...you’re not alone. One of the most common (and frustrating) side effects of these medications is constipation.

Let’s break down why this happens and how to get relief—without compromising your progress.

What Are GLP-1 Medications and How Do They Work?

GLP-1 receptor agonists work by mimicking the action of a naturally occurring hormone in your body. Their main functions include:

Stimulating insulin production in response to high blood sugar
Slowing down gastric emptying (how quickly food leaves your stomach)
Sending “I’m full” signals to the brain, reducing appetite

This combination helps regulate blood sugar and supports sustainable weight loss—but that same slowing of digestion is a key reason for the digestive side effects.

Why Do GLP-1s Cause Constipation and Bloating?

Slower digestion means food moves more gradually through the stomach and intestines. This can result in:

Constipation
Bloating and gas
Abdominal discomfort
Feeling full quickly, even after small meals
Fewer bowel movements or straining

For some people, these symptoms ease after the first few weeks of treatment. For others, constipation continues to interfere with daily comfort and overall wellbeing.

Natural Ways to Support Digestion on GLP-1s

The good news? Simple lifestyle changes and targeted supplements can make a big difference in relieving constipation without stopping your medication.

1. Stay Hydrated

Water is essential for healthy digestion. Aim for 8–10 cups per day to keep stools soft and support gut motility.

2. Move Your Body Daily

Light physical activity—especially walking after meals—stimulates the natural muscle contractions of your intestines, helping things move along.

3. Focus on Soluble Fiber

Add soluble fiber gradually into your diet:

Chia seeds
Flaxseed
Oats
Psyllium husk

⚠️ Important: Adding too much fiber too quickly can worsen bloating. Introduce it slowly with plenty of water.

4. Eat Smaller, Balanced Meals

Large or high-fat meals can worsen that "overly full" feeling. Opt for smaller, balanced meals that include lean proteins, fiber, and healthy fats.

Supplements That May Relieve Constipation from GLP-1s

Before starting any supplement, speak with your healthcare provider. That said, the following are commonly used to support digestion on GLP-1 medications:

Magnesium Citrate or Glycinate

These forms of magnesium help relax intestinal muscles, making it easier to pass stool. Glycinate is gentler, while citrate can have a stronger laxative effect.

Soluble Fiber Supplements

Fiber blends like acacia fiber or psyllium husk can add bulk and moisture to stool. Always increase fiber slowly and hydrate adequately.

Probiotics

Certain strains like Bifidobacterium lactis and Lactobacillus plantarum may reduce bloating and improve stool consistency.

Buffered Vitamin C

At higher doses, vitamin C can have a mild laxative effect while supporting immune function. Choose a buffered form to reduce stomach upset.

When to Talk to Your Doctor

If you experience any of the following, it’s time to check in with your provider:

Constipation lasting more than 3 days
Severe abdominal pain or cramping
Nausea or vomiting
No bowel movements for several days

Your provider may adjust your GLP-1 dosage, slow the titration schedule, or recommend additional support.

Takeaways: You Can Relieve GLP-1 Constipation Naturally

GLP-1 medications are powerful tools for managing blood sugar and weight—but they can slow digestion and cause uncomfortable side effects like constipation and bloating.

By:

Staying hydrated
Moving regularly
Adding the right kind of fiber
Choosing smart supplements

...you can improve your digestive comfort without stopping your medication.

Need Personalized Support for GLP-1 Side Effects?

Our licensed nutritionists and integrative pharmacists can help you:

Choose the right magnesium and fiber
Find gentle probiotic strains
Build a nutrition plan that supports gut health and GLP-1 tolerance

→ Book a private consultation with our team today and get tailored support on your health journey.

FAQ: Constipation on Ozempic, Mounjaro, and GLP-1s

Why do GLP-1 medications cause constipation?

They slow down gastric emptying and gut motility, which can lead to fewer bowel movements and harder stools.

How long does constipation from semaglutide last?

For many people, constipation improves after a few weeks. But others may need to make ongoing lifestyle or supplement changes for relief.

Can probiotics help with Mounjaro or Ozempic bloating?

Yes. Specific strains like Lactobacillus plantarum can reduce gas and support gut function.

What’s the best magnesium for GLP-1 constipation?

Try magnesium citrate for stronger relief or glycinate for a gentler option that supports both digestion and relaxation.

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