Brain Chemistry Panel


Brain Chemistry Panel

$290.00 $261.00

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Brain Chemistry Panel


This unique brain chemistry panel can help identify imbalances that are often associated with autism, Asperger’s syndrome, ADD/ADHD, anxiety, bipolar disorder, schizophrenia, assaultive/aggressive/violent behavior, and other mental and emotional conditions. Tests included in this panel are kryptopyrrole urinary quantitative, copper serum, zinc plasma, and whole blood histamine, which were modeled after the internationally recognized expert in the field of nutritional medicine and a key scientist paving the way for nutrient-based psychiatry and nutritional medicine, William Walsh, PhD, FACN.

Why this test is important:

By carefully evaluating a person’s individual biochemistry, a properly trained health provider can create a customized nutrient program. Because some people have abnormalities in all areas, while others might only have an imbalance in one, it is important to identify the specific imbalances for better, more focused treatment.

The nutrient therapies involved in correcting these biochemical imbalances are considered safe to use with most prescription medications commonly used for mood disorders. This allows for a very safe and gradually reduced dependency on the medication while the nutrient therapies have time to balance the biochemistry. In some cases, prescription medications may continue to provide added benefits to the nutrient therapies, in which case both can be continued indefinitely.

Who should be tested:

  • Individuals who suffer from attention deficit disorder, autism, mental depression, postpartum depression, schizophrenia, anorexia, bipolar disorder or any other behavior disorder

Test includes:

  • Kryptopyrrole urinary quantitative
  • Copper serum
  • Zinc plasma
  • Whole blood histamine
  • Ceruloplasmin

Test descriptions:

Kryptopyrrole Urinary Quantitative

Pyrrole disorder is characterized by an elevated urine kryptopyrrole, which results in a dramatic deficiency of zinc and vitamin B6. Pyroluria, Elevated Pyrroles, or a high Kryptopyrrole result, is frequently identified in behavior disorders, autism, aspergers, ADHD, ADD, depression, bipolar disorders, assaultive/aggressive/violent behavior, schizophrenia and other mental and emotional conditions. Pyroluria can create poor tolerance of physical and emotional stress, poor anger control, emotional mood swings, depression, anxiety, poor short term memory, frequent infections, inability to tan, poor dream recall, abnormal fat distribution, sensitivity to light and sound and tactile sensitivities. Requires an at-home urine collection.

Copper Serum

Copper serum is a highly reliable blood test that directly relates to brain chemistry. Elevated copper levels can alter the brains function, specifically lowering dopamine levels and raising norepinephrine levels. Imbalances in these essential brain chemicals have been related to paranoid schizophrenia, bi-polar disorder, postpartum depression, ADD, ADHD, autism, and violent aggressive behavior. Copper serum levels can single handedly be the root cause of an individual condition, but elevated copper serum levels are also known to cause zinc levels to deplete and oxidative stress to rise. Requires a blood draw.

Zinc Plasma

Functional levels of zinc, along with a copper/zinc ratio, are frequently performed as markers for specific neuro activity. More than 90% of people diagnosed with depression, behavioral disorder, ADHD, autism and schizophrenia exhibit depleted zinc levels. Zinc defiency has been associated with delayed growth, temper control problems, poor immune function, depression, poor wound healing, epilepsy, anxiety, neurodegenerative disorders, hormone imbalances and learning problems. Zinc and pyrrole levels coordinate. It has been clinically documented that low zinc levels can cause pyrrole levels to appear underrepresented. Requires a blood draw.

Whole Blood Histamine

Whole Blood histamine levels are a marker for methylation, a critical biochemical pathway necessary for the production of neurotransmitters such serotonin, dopamine, norepinephrine and epinephrine. Genetic abnormalities in methylation can result in either the overproduction or underproduction of these important brain neurotransmitters. People that overproduce neurotransmitters (over-methylators) often have high anxiety, panic disorders, and chemical sensitivities. Individuals who under-produce neurotransmitters (under-methylators) often exhibit depression, compulsive behaviors, and perfectionism. Requires a blood draw.


Ceruloplasmin is blood protein that binds to copper and plays a role in iron metabolism. Measuring ceruloplasmin and copper enables a practitioner to accurately calculate a patient’s free percentage of copper. Free copper is the amount of unbound copper circulating in the blood, unbound to ceruloplasmin. Individuals with more than 25% of their copper not bound to ceruloplasmin are considered to have elevated oxidative stress levels. This condition is common in autism, postpartum depression, ADHD, and certain forms of psychosis. Requires a blood draw.



Test Type:

  • Urine Collection
    • Detailed instructions will be sent to you with a test kit.
  • Blood test*
    • This test also requires blood work. A lab requisition form and necessary instructions will be sent along with the test kit. Take this form to a local LabCorp Patient Service Center. A trained professional will take your blood and mail the blood work directly to our lab.

Please note:

All tests are authorized and reviewed by a physician from our partner laboratory.


Results for this test can take up to 14 days.

You will also receive a brief analysis of your test results from a Village Green licensed nutritionist. We strongly recommend that for this particular test, you consult with a practitioner that has specific knowledge of this brain chemistry panel. Contact us if you’d like a practitioner recommendation.


Email a Village Green nutritionist or call 800-869-9159.

*Blood testing services are available only in the continental United States and Anchorage, AK. Not available in New York or New Jersey.

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Contact Us

For personalized health service, email a Village Green nutritionist or call 800-869-9159.