Trimethylglycine (TMG) is a more active “methyl donor” than DMG because it has an additional methyl group in its chemical structure. It is used to convert homocysteine to methionine.
TMG is found in a variety of plant and animal sources. Kirkman’s TMG derives from beets.
Methyl donors can help in the production of several brain chemicals. Some of the methione from TMG is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body that may support mood, energy, concentration, and a feeling of well-being.
Folic acid intake and levels in the body must be adequate for TMG to work biochemically. In some individuals, the use of natural folinic acid may be more beneficial than folic acid because folinic acid already has attached four hydrogen atoms and one methyl group, thereby shortcutting the complicated biochemical processes that assist purine and nucleotide synthesis. These processes are very important in cell perception and response.*