SAMe
Description
- Supports cognitive and liver function
- Helps maintain joint comfort
- Made with hypoallergenic, vegan ingredients
SAMe (S-Adenosylmethionine) is formulated to help maintain cognitive health, liver function, and joint comfort. SAMe also promotes healthy cell growth and positive mood.
Details :
SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. SAMe also functions as a precursor molecule for glutathione and promotes polyamine synthesis to promote healthy cellular function. Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells. SAMe also targets cognitive function and positive mood, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin. It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity. Studies suggest it may enhance joint comfort and flexibility as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to enhance joint comfort and function by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans.

Supplement Facts
Serving size: 1 capsule
| Amount per capsule | % DV | |
|---|---|---|
| SAMe (S-adenosylmethionine) |
200 mg | † |
† Daily Value (DV) not established.
Other ingredients: vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), calcium oxide, ascorbyl palmitate, calcium chloride
Suggested Use: 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.
Caution: If you are pregnant or lactating, have any health condition or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.
Just 3 Simple Steps Towards
A Healthier You
Easy ordering at your fingertips

Order today
Add the products you need from our online store and proceed to checkout.

We Ship With in 24 Hours
We ship within 24 hours excluding weekends and holidays. Tracking information will be sent to you via email.

Be Healthy & Happy
Optimize your health with our high-quality nutritional products and expert guidance.
A DIFFERENT KIND OF PHARMACY WHERE YOU'RE NEVER JUST A NUMBER
Trusted Reputation, Expertise, and Personalized Support
KNOWLEDGEABLE STAFF
- Expert pharmacists, nutritionists, herbalists, clinicians, and more.
- Personalized guidance tailored to each customer's unique needs.
- In-depth knowledge of drug, nutrient, herb interactions and depletions
Our integrative pharmacy offers comprehensive information on nutritional supplements, as well as drug-nutrient and drug-herb interactions and nutrient depletions — information that is not typically provided by most pharmacies.
CUSTOM COMPOUNDING SOLUTIONS
- Unique combinations of drugs and nutrients personalized to you.
- Accurate and customized dosages for optimal effectiveness.
- Many forms to choose from, including capsules, liquids, creams, and more.
For over 30 years, Village Green Apothecary's compounding pharmacy has excelled in custom formulations of nutrients (vitamins, minerals, amino acids), herbs, and prescription drugs. Our specially trained pharmacists can work with you to meet your unique needs.
IN-DEPTH NUTRITION & WELLNESS CONSULTATIONS
- One-on-one consultations, in person or via phone call.
- Tailored diet, supplement, and lifestyle recommendations to meet your health goals.
- In-depth knowledge of drug, nutrient, herb interactions and depletions
Working with a nutrition expert can help you address your health concerns and support you in achieving your health goals. Utilizing specialty lab testing, such as nutrient analysis, adrenal and hormone tests, and food sensitivity panels, can provide further important insights into your health.
Supporting Thousands On Their Wellness Path Every Day
Let customers speak for us
from 1121 reviews
Organic Bold Lash Mascara (Black)
I was already exercising and trying to eat right with no results. I added Calocurb 6 weeks ago and have already lost 5 pounds. I am very happy with the results and absolutely no side effects
Cranberry Concentrate
Just what the doctor ordered. Will order again when needed.
works for my sinus
It helped a lot with my stress!!
Joyful Creation (Sacral Chakra) Essential Oil
A good supplement for hair, nails and skin that actually works.
always appreciate your good quality supplements
Vitamin B-12 1000 MCG
Loving Compassion (Heart Chakra) Essential Oil Pre-Diluted Roll-On
DIGITALIS PURPUREA 200CK MD
I am very happy with Village Green’s products and fast, reliable delivery of orders.
Used this product to relieve constant digestion, gas and bloating. Immediately helped me pass gas and use the bathroom. Suffer from constipation and sibo and this knockdown bad bacteria overrunning my gut. Strong you will hear at first so take slow.
Self Manifestation (Solar Plexus Chakra) Essential Oil Pre-Diluted Roll-On
FREQUENTLY ASKED QUESTIONS
What makes Village Green different?
As a leading integrative pharmacy, we have over 10,000 nutritional supplements
Why should I choose Pathway supplements?
Where are you located?
What is your return policy?
MORE SUPPLEMENTS FOR A HEALTHIER YOU


WHY WAIT?
GRAB IT NOW!
Description Supports cognitive and liver function Helps maintain joint comfort Made with hypoallergenic, vegan ingredients SAMe (S-Adenosylmethionine) is formulated to help maintain cognitive health, liver function, and joint comfort. SAMe also promotes healthy cell growth and positive mood. Details : SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over ...

Village Green Apothecary
5415 W Cedar Ln
Bethesda, Maryland, 20814
(301) 530-0800
Toll Free: (800) 869-9159
The information provided on this site is not intended to be a substitute for advice or treatment from a qualified physician, nor is it intended to diagnose or treat a health problem or disease. Consult your physician prior to starting any new health program or if you any questions regarding a medical condition.
© 2025 Village Green Apothecary - All Rights Reserved.

