# 5-Hydroxytryptophan

5-Hydroxytryptophan (5-HTP) is the intermediate metabolite produced when the body initiates the process of converting the essential amino acid L-tryptophan to serotonin. Serotonin levels in the body are associated with the regulation of sleep, mood, aggression, appetite, temperature, sexual behavior, and pain sensation.\*

Supplementing with 5-HTP to facilitate serotonin production is preferable to supplementing with L-tryptophan because, unlike L-tryptophan, 5-HTP cannot be shunted into niacin or protein production.\* Supplementation with 5-HTP bypasses the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase, the rate-limiting step in the synthesis of serotonin and a step that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.

5-HTP is well absorbed when taken orally, with about 70 percent ending up in the bloodstream.\*

Intestinal absorption of 5-HTP does not require the presence of a transport molecule and is not affected by the presence of other amino acids; therefore, it may be taken with meals without reducing its effectiveness.\* 5-HTP easily crosses the blood-brain barrier and effectively increases central nervous system (CNS) synthesis of serotonin.\*

5-HTP has been shown to have a beneficial impact on mood, discomfort associated with fatigue, sleep, and carbohydrate craving.\* Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.\*

To further facilitate serotonin production, Thorne Research's 5-HTP formula contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin.\* 5-HTP is commercially produced by extraction from the seeds of the African plant, _Griffonia simplicifolia_.

**Two Capsules Contain:**  
**Vitamin B6 (as Pyridoxal 5'-Phosphate)** 6.8 mg.  
**5-Hydroxytryptophan** 100 mg.

**Other Ingredients:** Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

## Details

- **Price:** 39.0 USD
- **Vendor:** THORNE RESEARCH
- **Type:** Vitamins & Supplements
- **Tags:** $30 to $40, 30 Day Supply, 90 CP, DR LINE SUPPLEMENT, flash, Form|CP, SyncedWithC4, THORNE RESEARCH

## Variants

| Variant | Price | Available |
|---------|-------|-----------|
| Default Title | 39.00 USD | In stock |

## Images

- 5-HTP - Thorne
- 5-Htp - My Village Green
- 5-Htp - My Village Green

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> Source: [Village Green Apothecary](https://myvillagegreen.com/products/thorne-research-5-htp-90-capsules)
> Updated: 2026-05-04