# SAMe - 400mg

_400 mg / 30-60 Enteric-Coated Tablets / 1-2 Months Supply_

**Jarrow Formulas** **SAM_e_ 400** provides a full 400 mg SAM_e_ (net yield) from 800 mg of SAM_e_ tosylate disulfate. SAM_e_ 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

**With More of the Biologically Active S,S than R,S Form**  
Found in all living cells, SAM_e_ is a metabolite of methionine (an essential amino acid). SAM_e_ is a chiral molecule consisting of two forms: (S,S) SAM_e_ and (R,S) SAM_e_. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.

**Jarrow Formulas** SAM_e_ is made naturally by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAM_e_.

SAM_e_ supports:

**Brain Metabolism and Mood**  
SAM_e_ methylation reactions are involved in the synthesis of  
phosphatidylcholine, a substantial constituent of grey matter within the  
brain and cellular membranes. It has also been proposed to be involved  
in the formation or metabolism of neurotransmitters, which helps to  
support a balanced mood.

**Joint Health**  
SAM_e_ supports the production of healthy connective tissue through  
transsulfuration. In this transsulfuration process, critical components  
of connective tissue known as glycosaminoglycans (GAGs), including  
glucosamine and chondroitin, are sulfated by SAM_e_ metabolites to  
yield sulfated GAGs, such as glucosamine sulfate and chondroitin  
sulfate, the building blocks of cartilage.

**Liver Function**  
SAM_e_ supports the synthesis of glutathione (GSH), which is  
critical for antioxidant defenses and liver functions including phase  
II detoxification.

-   Supports: Joint Health, Brain Metabolism and Mood, Liver Function
-   Enteric-Coated
-   68-80% Active S,S Form
-   Made Naturally By Fermentation
-   Individually Blister-Packed

**SUGGESTED USE**

Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.

**WARNING:** Do not use if pregnant or nursing. Individuals with Parkinson’s disease, bi-polar disorder, or manic depression should not use this product. May cause gastrointestinal upset in some persons. Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.

KEEP OUT OF THE REACH OF CHILDREN.

STORE IN A COOL, DRY PLACE.

## Details

- **Price:** 36.74 USD
- **Vendor:** JARROW FORMULAS
- **Type:** Vitamins & Supplements
- **Tags:** $30 to $40, 30 Day Supply, 30 TB, Form|TB, Hidden recommendation, JARROW, JARROW FORMULAS, Mood & Anxiety, SyncedWithC4

## Variants

| Variant | Price | Available |
|---------|-------|-----------|
| Default Title | 36.74 USD | In stock |

## Images

- SAMe - 400mg
- SAMe - 400mg

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> Source: [Village Green Apothecary](https://myvillagegreen.com/products/jarrow-formulas-sam-e-400-jarrow-formulas-30-tablets)
> Updated: 2026-05-24